Cairo is the eleventh biggest city in the world and the capital of Egypt. Annoyance of workers from Cairo international airport noise levels was studied. 260 workers at 20 selected locations with different noise levels in offices, arrival, and departure halls were evaluated. The goals of this study are to carry out measurements to evaluate noise levels within airport, are if these levels exceeded the permissible levels set by Egyptian noise standard and policy to protect public health of workers?, to carry out experiments to reduce airport noise levels as: effect of distance from runway, numbers of movements, and types of aircrafts, to examine worker's attitudes towards airport noise, to know the relationship between airport noise levels and degree of annoyance. The results of the measurements showed that aircraft noise level inside building were 84 dB. Annoyance of respondents showed that 42.8 % were highly annoyed, 4.6 % their hearing were harmed. There was a strong relationship between airport noise levels and percentage of highly annoyed respondents. By increasing airport noise level possibility of workers to make mistake in their work was also increased