Secondary flows are noxious to axial compressor performance. To overcome and control those secondary flows, vortex generators are used as a passive control device. Controlling secondary flows will lead to a further improvements in the compressor performance. A new design of vortex generator is considered in this investigation in order to control secondary flows in axial compressor cascade at design and off-design conditions. Numerical simulations of a three-dimensional compressible turbulent flow have been performed to explore the effect of the vortex generators on the reduction of secondary flows. Six different incidence angles are used for the off-design operation investigations. Based on the simulation results, the pressure, velocity, and streamline are used to follow up the development of the secondary flows. Thence, total pressure loss coefficient, static pressure rise coefficient, difference in flow deflection angle, and diffusion factor are estimated. Results indicate that vortex generators have a significant effect on the development of secondary flows at off design operation as they cause a reduction in total pressure loss, they also affect the loading behavior of the cascade as they cause a slight change in the cascade deflection, and a slight decrease in the diffusion factor which causes unloading of the blade. Static pressure rise is significantly reduced at negative incidence angles while a slight reduction occurs at positive incidence angles. In a word, the new design of the vortex generator enhances the cascade aerodynamic performance and enlarges the operating range of the cascade towards the positive incidence region.