The role of ITPA and ribavirin transporter genes polymorphisms in prediction of ribavirin‐induced anemia in chronic hepatitis C Egyptian patients

Faculty of Medicine

Assiut University

The role of ITPA and ribavirin transporter genes polymorphisms in prediction of ribavirin‐induced anemia in chronic hepatitis C Egyptian patients

Research Authors
Ehab S El Desoky, Alaa T Abdelhafez, Jessica Cusato, Sherif I Kamel, Abeer MR Hussein, Amedeo De Nicolo, Giovanni Di Perri, Antonio D'Avolio
Research Department
Department of Pharmacology
Research Journal
Clinical and Experimental Pharmacology and Physiology
Research Member
Abeer Mohamed Rashad Hussein Gomaa
Research Publisher
NULL
Research Rank
1
Research Vol
NULL
Research Website
NULL
Research Year
2017
Research_Pages
NULL
Research Abstract

Few data are available concerning the roles of polymorphisms of inosine triphosphatase (ITPA) gene and ribavirin (RBV) transporter genes in the prediction of RBV-induced anemia among Egyptians with chronic hepatitis C (CHC). Genotyping of 3 ITPA gene variants and 2 variants of RBV transporter genes has been performed in 123 patients under pegylated interferon-α/ribavirin treatment. The baseline hemoglobin and ITPA rs1127354 CA/AA have been found as predictors of anemia at 4, 8 and 12 weeks of RBV therapy. In addition, ITPA rs7270101 AC/CC and age predicted anemia after 12 weeks of therapy. In conclusion, the ITPA variant rs1127354C>A significantly predict RBV-induced anemia during the first 3 months of treatment and it is recommended to be assessed before RBV administration.