Background and aim of work: We aimed from this study to determine the
response and local relapse free survival (RFS) of pediatric patients with localized Ewing’s sarcoma treated with accelerated hyper-fractionated RT. Patient and methods: This study was a nonrandomized uncontrolled phase II
study and was conducted at clinical oncology department and south Egypt
cancer institute; it involved 28 patients with histologically confirmed Ewing’s
sarcoma; all of them were subjected to PET/CT whenever possible or MRI with
contrast of the primary site, MSCT chest, bone scan, and LDH to ensure absence of metastasis followed by the protocol of accelerated hyper fractionated
RT. Results: The overall response rate (ORR) was 92.9% by MRI with significant effect of the type of response on local RFS (P < 0.002). The median local
RFS of 28 patients with localized Ewing’s sarcoma was 30 ± 8.599 months with
95% CI = 13.147 - 46.853; the 3-year local control was 35%. Conclusion: Accelerated hyper fractionated RT didn’t achieve better results than standard fractionation RT, but it is recommended to be done on a large sample size, and
multiple centers, and continued follow up is also recommended to evaluate
5-year LRFS, 5-year OS.