Evaluation of the impact of laparoscopic ovarian drilling on Doppler indices of ovarian stromal blood flow, serum vascular endothelial growth factor and insulin-like growth factor-1 in women with polycystic ovary syndrome.

Faculty of Medicine

Assiut University

Evaluation of the impact of laparoscopic ovarian drilling on Doppler indices of ovarian stromal blood flow, serum vascular endothelial growth factor and insulin-like growth factor-1 in women with polycystic ovary syndrome.

Research Authors
Ahmed F Amin, Diaa-Eldeen M Abd el-Aal, Atef M Darwish, Abdel-Raheim M A Meki
Research Department
Department of Obstetrics and Gynecology
Research Journal
Journal of Fertility and Sterility.
Research Member
Atef Mohamed Mostafa Darwish
Research Publisher
NULL
Research Rank
1
Research Vol
VOLUME 79, ISSUE 4
Research Website
DOI:https://doi.org/10.1016/S0015-0282(02)04849-5
Research Year
2003
Research_Pages
938-941
Research Abstract

Abstract
Objective: To study the serum levels and correlation of vascular endothelial growth factor (VEGF), insulin-like growth factor 1 (IGF-1), hormonal profile, and Doppler blood flow changes within the ovarian stroma before and after laparoscopic ovarian drilling (LOD) in women with clomiphene-resistant polycystic ovary syndrome (PCOS).

Design: Prospective controlled study.

Setting: University teaching hospital.

Patient(s): Twenty-five women with clomiphene-resistant PCOS (group 1) and 20 women with regular menstrual cycles as a comparison group (group 2).

Intervention(s): Laparoscopic ovarian drilling.

Main outcome measure(s): Serum levels of VEGF, IGF-1, and Doppler indices of ovarian stromal blood flow.

Result(s): The serum levels of VEGF, IGF-1, T, and LH were significantly higher in group 1 before LOD than in group 2. The Doppler indices (pulsatility index and resistance index) of ovarian stromal blood flow were also significantly lower in group 1 before LOD than in group 2. The serum levels of VEGF, T, and LH were significantly reduced in group 1 after LOD compared with in group 1 before LOD. Doppler indices (pulsatility index and resistance index) of ovarian stromal blood flow were significantly increased after LOD. The VEGF levels before LOD were positively correlated with IGF-1, LH, and T. After LOD, the VEGF levels were positively correlated with LH and T.

Conclusion(s): Higher serum levels of VEGF and IGF-1 may explain the increased vascularity that was demonstrated by Doppler blood flow measurements in PCOS. Laparoscopic ovarian drilling reduced serum VEGF, IGF-1, T, and LH and reduced ovarian blood flow velocities, which may explain the reduction of ovarian hyperstimulation syndrome in women with PCOS after LOD.