Uterine artery Doppler blood flow in cases of hydatidiform mole and its correlation with beta-hCG

Faculty of Medicine

Assiut University

Uterine artery Doppler blood flow in cases of hydatidiform mole and its correlation with beta-hCG

Research Authors
Diaa Eldeen M Abd El Aal 1, Elwany D El Senosy, Momen A Kamel, Maha Atwa
Research Department
Department of Obstetrics and Gynecology
Research Journal
European Journal of Obstetrics and Gynecology and Reproductive Biology.
Research Member
Diaa Eldeen Mohamed Abd El Aal Abd El Hafez
Research Publisher
Elsevier
Research Rank
1
Research Vol
10;111(2)
Research Website
DOI: 10.1016/s0301-2115(03)00282-3
Research Year
2003
Research_Pages
129-34
Research Abstract

Abstract
Objectives: To study the correlation between Doppler blood flow and beta-human chorionic gonadotropin (hCG), to assess the course of the disease and the follow up evaluation.

Setting: This study was conducted in Assiut University Hospital, Department of Obstetrics and Gynecology.

Design: Longitudinal study.

Subjects and methods: Fifteen cases of vesicular mole were recruited and followed up. The patients were evaluated the day before evacuation of the uterus. This included clinical assessment, Doppler uterine artery blood flow velocity waveforms using the Doppler indices and assessment of the serum level of beta-hCG. These cases were followed up every 2 weeks in the first 2 months, and every month thereafter until the 6 month.

Results: Twelve patients showed continuous decrease in beta-hCG level from 1192+/-697 to 6+/-11 IU/ml by the end of the second month. Systolic-diastolic (S/D) increased from (2.57+/-1.13) to (15.9+/-2.07) (P<0.0001), RI increased from 0.55+/-0.15 to 1.0+/-0.26(P<0.0001) and PI increased from 1.02+/-0.47 to 6.12+/-2.34 (P<0.0001). One patient showed a fluctuating level of beta-hCG around the same level, and two showed a slowed decrease. Doppler indices showed similar results. There is a strong correlation between beta-hCG and all Doppler indices throughout the course of follow up: beta-hCG and S/D r<0.01, beta-hCG and RI r<0.01 and beta-hCG and PI r<0.01.

Conclusion: Doppler ultrasound can be used as an adjuvant tool in the follow up of cases of vesicular mole and can predict the progress in the course of the disease.