Efficacy of intraoperative use of tranexamic acid in reducing blood loss from telescoping nail application in osteogenesis imperfecta. A randomized controlled trial

Faculty of Medicine

Assiut University

Efficacy of intraoperative use of tranexamic acid in reducing blood loss from telescoping nail application in osteogenesis imperfecta. A randomized controlled trial

Research Authors
Hesham Mohamed Elbaseet Abdelghani
Research Date
Research Department
Department of Orthopedic Surgery and Traumatology
Research Journal
Orthopaedics & Traumatology: Surgery & Research
Research Member
Hesham Mohamed Elbaseet Abdelghany
Research Publisher
Elsevier B.V.
Research Rank
Q1
Research Vol
In Press, Corrected Proof
Research Website
https://www.sciencedirect.com/science/article/abs/pii/S1877056824001749
Research Year
2024
Research_Pages
5
Research Abstract
Background
Osteogenesis imperfecta (O.I) is a rare disease caused by an abnormality in type 1 collagen synthesis leading to repeated fractures after low-energy trauma and progressive long bones deformity. Telescoping nail application and surgical correction of these deformities usually necessitates multiple osteotomies and significant bleeding occur due to weakened capillaries and impaired platelet activity. Tranexamic acid (TXA) has an antifibrinolytic effect which is useful in reducing bleeding and need for blood transfusions following several orthopaedic procedures.
Hypothesis
The use of intraoperative (Local and Intravenous) tranexamic acid reduces blood loss during femoral telescoping nail application in O.I. patients.
Material and methods
A prospective randomized controlled study was carried out on 40 patients during applying femoral telescoping nail divided into Group A: (case TXA); 20 patients receiving …