Abstract
Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking. Serial reactions including dehydrogenation, demethylations, reduction, glycosylation and methylation have been observed after incubation of tanshinone IIA and fungus Mucor rouxianus AS 3.3447. In addition, tanshinosides B (2) showed potent activities against serial clinical isolates of oxacillin-resistant Staphylococcus aureus with MIC values of 0.78 μg/mL. This is the first study that shows a significant increase in the level and activities of tanshinone glycosides relative to the substrate tanshinone IIA.
قسم البحث
مجلة البحث
Synthetic and Systems Biotechnology
الناشر
Sciencedirect
تصنيف البحث
1
عدد البحث
1
موقع البحث
http://www.sciencedirect.com/science/article/pii/S2405805X15300223
سنة البحث
2016
المشارك في البحث
ملخص البحث