An Experimental and Computational Study on the Epimeric Contribution to the Infrared Spectrum of Budesonide

Faculty of Pharmacy

Assiut University

An Experimental and Computational Study on the Epimeric Contribution to the Infrared Spectrum of Budesonide

Research Authors
H. R. H. Ali, H. G. M. Edwards, J. Kendrick, T. Munshi, I. J. Scowen
Research Department
Department of Pharmaceutical Analytical Chemistry
Research Journal
Drug Test. Analysis, DOI: 10.1002/dta.152
Research Rank
1
Research Vol
Vol. 2, No. 9
Research Year
2010
Research Member
Hassan Refat Hassan Ali
Research Abstract

Budesonide is a mixture of 22R and 22S epimers. The epimeric content of budesonide was reported in both British and European pharmacopoeias to be within the range of 60–49/40–51 for R and S epimers, respectively. In this work, contribution of the two epimers to the overall infrared spectrum of budesonide has been investigated by quantum chemical calculations.