Staphylopeptide A, a new cyclic tetrapeptide from culture broth of Staphylococcus sp.

Faculty of Pharmacy

Assiut University

Staphylopeptide A, a new cyclic tetrapeptide from culture broth of
Staphylococcus sp.

Research Authors
Amgad I.M. Khedr , Gamal A. Mohamed , Mohamed A.A. Orabi , Sabrin R.M. Ibrahim , Koji Yamada
Research Department
Department of Pharmacognosy
Research Journal
Phytochemistry Letters
Research Publisher
Elsevier
Research Rank
1
Research Vol
13
Research Website
http://dx.doi.org/10.1016/j.phytol.2015.05.007
Research Year
2015
Research Member
Sabrin Ragab Mohamed Ibrahim
Research Abstract

Re-investigation of the culture broth of the marine bacterium Staphylococcus sp. (no. P-100826-4-6)
afforded a new cyclic tetrapeptide namely staphylopeptide A (1), along with five known compounds,
cyclo (L-prolyl-L-valine) (2), cyclo (L-prolyl-L-tyrosine), (3), cyclo (L-prolyl-L-alanine) (4), L-phenylalanine (5), and L-tryptophan (6). The structures of the isolated compounds were determined by extensive IR, 1D (1H and 13C) and 2D (1H-1H COSY, HSQC, HMBC, and NOESY) NMR and HRFABMS spectral measurements.
The antimicrobial activity of the isolated compounds (1–6) was evaluated.