Sagitol C, a new cytotoxic pyridoacridine alkaloid from the sponge Oceanapia sp.

Faculty of Pharmacy

Assiut University

Sagitol C, a new cytotoxic pyridoacridine alkaloid from
the sponge Oceanapia sp.

Research Authors
Sabrin RM Ibrahim, Gamal A Mohamed, Ehab S Elkhayat, Mostafa A Fouad, Peter Proksch.
Research Department
Department of Pharmacognosy
Research Journal
Bulletin of Faculty of Pharmacy, Cairo University (2013) 51, 229–232
Research Publisher
Elsevier
Research Rank
2
Research Vol
51
Research Website
http://dx.doi.org/10.1016/j.bfopcu.2013.05.004
Research Year
2013
Research Member
Sabrin Ragab Mohamed Ibrahim
Research Abstract

A new pyridoacridine alkaloid named sagitol C (2) together with two known compounds; kuanoniamine C (1) and sagitol (3) were isolated from the EtOAc fraction of the Indonesian sponge Oceanapia sp. Their chemical structures were established on the basis of physical and
spectroscopic methods 1D and 2D NMR, in addition to mass spectrometry and comparison with
literature data. Sagitol C was found to exhibit cytotoxic activity when tested against different cancer
cell lines