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Two New Polyhydroxylated Steroids from Egyptian Soft Coral Heteroxenia fuscescens (Fam.; Xeniidae)

Research Authors
Fahd M. Abdelkarem, Ezz-Eldin K. Desoky, Alaa M. Nafady, Ahmed E. Allam, Aldoushy Mahdy, Ahmed Ashour, Gamal A. Mohamed, Tomofumi Miyamoto, Kuniyoshi Shimizu
Research Department
Research Journal
Natural Product Research
Research Publisher
NULL
Research Rank
1
Research Vol
Published Online
Research Website
https://doi.org/10.1080/14786419.2019.1624958
Research Year
2019
Research Abstract

Two new polyhydroxylated steroids, 3b-acetoxy-gorgost-5a,6b,11a-triol (3) and (23 R) methylergosta-20-ene-3b,5a,6b,17atetrol (4), together with three known gorgosteroid compounds, gorgost-3b, 5a,6b,11a- tetrol (1), 11a-acetoxy-gorgost- 3b,5a, 6btriol (2), and gorgost-5 (E) ene-3-b-ol (5), as well as batyl alcohol (6), were isolated from the Egyptian soft coral Heteroxenia fuscescens. The structures of these compounds were elucidated based on NMR spectroscopic analyses, HR-FAB-MS, and comparisons with published data. The cytotoxic activities of the fractions and compounds were evaluated against MCF-7 cancer cell lines using MTT colorimetric assay. Compounds 2 and 4 showed moderate cytotoxic activity, with IC50 values equal to 33.2 and 25.1 mM, respectively, in comparison with the IC50 of 5-fluorouracil 18.7 mM.