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Synthesis and biological activity of pyrazolothienotetrahydroisoquinoline and [1,2,4]triazolo[3,4-a]thienotetrahydroisoquinoline derivatives

مؤلف البحث
Adel M. Kamal, Shaban M. Radwan, Remon M. Zaki
ملخص البحث

1-Hydrazino-3-thioxo-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile (3) was subjected to react with
bifunctional compounds namely: acetylacetone, ethyl cyanoacetate, ethyl benzoylactate, diethylmalonate
and ethyl acetoacetate to produce pyrazololthienotetrahydroisoquinoline derivatives 6e11. Also, heating
of compound (3) with formic acid afforded triazolothienotetrahydroisoquinoline compound 5 which
reacted with a-halogenated compounds to afford compounds 13aee. Compound 13c when heated with
triethylorthoformate afforded triazolo derivative 14. Also, compound 6 was used for synthesizing
compounds 18e20. Representative compounds of the synthesized triazolo and pyrazolothienotetrahydroisoquinoline
products were tested and evaluated as antimicrobial agents.

قسم البحث
مجلة البحث
European Journal of Medicinal Chemistry
المشارك في البحث
تصنيف البحث
1
عدد البحث
Vol. 46
موقع البحث
http://www.elsevier.com/locate/ejmech
سنة البحث
2011
صفحات البحث
PP. 567-578