A new series of spirothiazolidinone polymers has been accomplished by solution polycondensation
of 4,12-dioxa-1,9-dithiadispiro[4.2.4.2]tetradecane-3,11-dione (3) with different aliphatic and
aromatic diamines. A model compound 4 was prepared by the reaction of spiro-monomer 3 with
benzyl amine and was characterized by elemental and spectral analyses. These polymers were
characterized by elemental and spectral analyses. The thermal properties of these polymers were
investigated by thermogravimetric analysis and differential thermal analysis measurements. The
morphological properties of selected polymers 5c and 5e were tested using scanning electron
microscope to study their surface morphology. The molar masses of polymers 5a, 5b, and 5d were
determined by gel permeation chromatography. In addition, the anti-inflammatory activities were
studied for these spiro-polymers in comparison with the model compound by determination in vivo
using acute carrageenan-induced paw edema in rats.