The past decade witnessed significant progress in the preparation, characterization, and applications of advanced materials, e.g. nanoparticles. The recent techniques for materials processing could enable new devices. Thus, several innovative processing technologies for the implementation of materials, including nanoparticles, into small devices are now available. The rapid pace of progress in the area of analytical devices improved methods of detection, sensing, and biosensing. Miniaturized and portable devices are required urgently for on-site analytical applications. Several types of miniaturized and wearable devices are being developed for the measurement of key analytes and biomarkers without the need for invasive procedures. There is a need to establish connections between academic laboratories and industrial sectors with required experimental facilities and infrastructures to create commercial products. New miniaturized devices could become useful for several applications including metal detection, sensing and biosensing, biomedical, and diagnostic applications. This chapter provides an in-depth understanding of the implementation of materials for miniaturized analytical devices. It is also noteworthy that using nanoparticles for miniaturized devices will benefit not only the electronics but also the chemical industries, as well as health-care industry. Interaction among scientists and engineers with different backgrounds will undoubtedly create miniaturized analytical devices with unforeseen technological possibilities.