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Synthesis and Reactions of
1-Amino-5-morpholin-4-yl-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline

Research Authors
Remon M. Zaki, Shaban M. Radwan and Adel M. Kamal El-Dean
Research Abstract

The pyrazolone derivative 4 was synthesized by reaction of carbohydrazide 2 with ethyl benzoylacetate
in ethanol and p-toluene sulphonic acid followed by cyclization upon heating in acetic acid.
Chloroacylation of amino ester and amino benzoyl compounds 1, 19 gave the chloro acetylamino derivatives
5 and 20 respectively which both of them react with different amines to afford compounds 6, 23a-d.
Hydrolysis and decarboxlation of compound 1 yielded the aminothienotetrahydroisoquinoline 8 which
was used as versatile material for synthesizing other heterocyclic compounds 9-18. Compound 20 react
with hexamethylenetetramine and malononitrile yielded thediazepino and pyrrolo derivatives 21, 22 respectively.

Research Department
Research Journal
Journal of the Chinese Chemical Society
Research Member
Research Rank
1
Research Vol
Vol. 58
Research Year
2011
Research Pages
PP. 544-554