Southwest Egypt is an arid area with no surface water and limited resources of useable groundwater in the well-known Nubian Sandstone Aquifer System. These groundwater reserves have been heavily exploited since the 1960s, which has led to substantial decline in the potentiometric surface of the aquifer. A calibrated regional numerical model with refined grids on the pumping centers has been used to investigate the hydrodynamic impacts of different groundwater management options on the potentiometry of the aquifers. The results indicate that there is a real danger of either dewatering the shallow aquifer in some areas (e.g., Kharga Oasis), or increasing the water depth to uneconomic lifting depth. They also indicate that, although the planned extraction rates in Dakhla, Farafra, and Bahariya oases are feasible for at least the coming 100years, the present rate for Kharga Oasis and the planned rate for the East Oweinat area have to be reduced substantially.