The purpose of this study was to describe the flora and vegetation of Qift-Qusier roadside in the central part of the Eastern Desert of Egypt, and to relate the floristic composition to the prevailing environmental conditions. A total of 61 species (28 annuals and 33 perennials) belonging to 50 genera and 27 families were recorded. Based on their presence values, classification of the 61 species recorded in 43 stands using the cluster analysis yielded 6 vegetation groups. Results of CCA ordination indicated that organic matter, Na, K, Ca and pH, were the most important factors for the distribution of the vegetation pattern along the road verges in the study area. The DCA and CCA results suggest a strong association between vegetation and the measured environmental parameters.