Detection of mefenamic acid (M, non-steroidal anti-inflammatory drug, NSAIDs) and its metallodrug was investigated using electrospray ionization mass spectrometry (ESI-MS) and fluorescence spectroscopy. ESI-MS data (500 µL, 1× 10-3 M) revealed high detection sensitivity for the drug and metallodrug. ESI-MS spectra revealed peaks at 242, 580, and 777 Da corresponding to [M+ H]+,[63Cu (MH) 2 (H2O) 2+ H]+, and [56Fe (MH) 3+ H]+, respectively. The metal: mefenamic ratios of ESIMS spectra are in complete agreement with the fluorescence spectroscopy results (1: 2 for Cu (II) and 1: 3 for Fe (III)). ESI is a soft ionization technique that can be used on labile metallo-mefenamic acids and is promising for the detection of these species in environmental samples and biological fluids.
Research Abstract
Research Department
Research Journal
Mass Spectrometry Letters
Research Member
Research Publisher
NULL
Research Rank
1
Research Vol
6
Research Website
NULL
Research Year
2015
Research Pages
43-47