Thiazolopyrimidnes are considered one of the most interesting classes in heterocyclic chemistry
due to their pharmaceutical importance. Herein, we report the synthesis of some new heterocyclic
compounds containing thiazolopyrimidine starting from compound (1) which was previously
prepared in literature. The starting compound was allowed to react with different alkylating
agents such as chloroacetone, chloroacetyl chloride, and phenacyl bromide to afford derivatives
(2-4). Compound (5), benzylidene derivative, was obtained by the reaction of compound (2) with
benzaldehyde while amino-dicarbonitrile compound (6) can be obtained by the reaction of
compound (5) and malononitrile. Acetylation of amino group in compound (6) with chloroacetyl
chloride led to formation of compound (7). Nucleophilic substitution of chlorine in compound
(7) by aniline gave compound (8) which further subjected the Munich reaction to form compound
(9). All new synthesized compounds were characterized using different elemental and spectral
analysis.