Three interesting thermoresponsive branched oligoethylene glycol dendrimers based on tetrabromohydroquinone
were efficiently synthesized from tetrabromohydroquinone and three different
oligoethylene glycol derivatives. By visual inspection, all these dendrimers are water-soluble at room
temperature. The thermoresponsive behaviors were investigated by using UV/vis turbidity measurement
at different temperatures for 0.25 wt% of aqueous solutions from D1, D2 and D3. The cytotoxicity of the
prepared dendrimers was tested against MCF-7 breast cancer cells. All tested dendrimers showed
considerable results, where D2 dendrimer gave the best result; it showed cytotoxicity against MCF-7 cell
line with IC50 of 1.07 mg/mL and resistant fraction equals 1.97%, the other two dendrimers showed a
modest cytotoxic profile.