Feasibility of breast conservation after neoadjuvant taxene based chemotherapy in locally advanced breast cancer: a Prospective Phase I trial

South Egypt Cancer Institute

Assiut University

Feasibility of breast conservation after neoadjuvant taxene based chemotherapy in locally advanced breast cancer: a Prospective Phase I trial

Research Authors
Mohamed I El-Sayed, Doaa W Maximous, Mohamed A Aboziada, Mostafa E Abdel-Wanis, Nabiel NH Mikhail
Research Member
Mohamed Ibrahim Mohamed El-Sayed
Research Department
Department of Radiotherapy and Nuclear medicine
Research Year
2010
Research Journal
Ann Surg Innov Res
Research Rank
1
Research Abstract

Neoadjuvant chemotherapy is the standard care for locally advanced
breast cancer. Our study aimed at evaluating the feasibility of breast conversation surgery
(BCS) after neoadjuvant chemotherapy. Patients and methods: Forty five patients had stage
IIB (except those with T2N1 disease) and stage IIIA were selected to 3 cycles taxane-based
neoadjuvant chemotherapy. Patient who had tumours≤ 5 cm underwent a tentative BCS
while patients who had tumour size> 5 cm underwent radical surgery. Negative margin is .