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Risk-based combined-modality therapy of pediatric Hodgkin's lymphoma: A retrospective study

Research Authors
Amany Ali, Heba Sayed, Ahmed Farrag and Mohamed El-Sayed
Research Department
Research Year
2010
Research Journal
Leukemia Research
Research Publisher
NULL
Research Vol
Vol. 34, Issue 11
Research Rank
1
Research_Pages
PP. 1447-1452
Research Website
NULL
Research Abstract

We conducted a retrospective analysis to investigate the clinical outcome of combined-modality therapy using multiagent chemotherapy and involved-field radiotherapy in treatment of children with Hodgkin's lymphoma. Fifty eight cases with newly diagnosed Hodgkin's lymphoma were analyzed. The median follow-up duration was 46 months (range 3–72 months). The 4-year overall and event-free survival rates were 91.5% and 69.7% respectively. High-risk disease (stage IIIB and IV), presence of B symptoms, lymphocyte depletion subtype, bulky disease and late response to chemotherapy were poor prognostic factors. Stage-adapted combined-modality therapy resulted in satisfactory outcome in treatment of pediatric Hodgkin's lymphoma.