Abstract
Background and aim: Gastric cancer represents the fifth most common cancer worldwide and the fourth most common cause of cancer related death. In recent years many studies focused on the increased incidence of signet ring cell carcinoma (SRCC) which is considered a poorly cohesive carcinoma with poor prognosis, this study aims to define any significant difference in clinical presentation and survival between gastric SRCC and non-signet ring cell carcinoma ( non-SRCC).
Results: There was no significant difference between non-SRCC and SRCC as the one year OS was 18% for nonSRCC and 17 % for SRC while the two year OS was 5% and 4% respectively, the median OS for non-SRCC was 7 months and for SRC was 7.5 months with p-value = 0.669. While one year PFS reached 30% in non-SRCC and 18% for SRC, and two year PFS was 11% for non-SRCC and 10% for SRC, the median PFS for non-SRCC reached 5 months and 5.5 months for SRC with p-value=0.494.
Conclusions: There was no significant difference between SRCC and non-SRCC in terms of OS and PFS.
Keywords: gastric SRCC, gastric non-SRCC, survival.