Fms-Like Tyrosine Kinase 3 expression in Childhood Acute lymphoblastic Leukemia at South Egypt Cancer Institute, Assiut University, Egypt

South Egypt Cancer Institute

Assiut University

Fms-Like Tyrosine Kinase 3 expression in Childhood Acute lymphoblastic Leukemia at South Egypt Cancer Institute, Assiut University, Egypt

Research Authors
AMZ, Heba Abdel Razik, SalahSaleh Abdel Hadi
Research Member
Asmaa Mohamed Zahran Omar
Research Department
Department of Clinical Pathology
Research Year
2014
Research Journal
SECI oncology
Research Rank
2
Research Abstract

FMS-Like Tyrosine kinase 3 (FLT3) plays an important role in early stages of hematopoiesis. FLT3 stimulation enhances proliferation and reduces apoptosis. One potential mechanism of FLT3 involvement in leukemia is over expression of its wild type and its ligand. The FLT3 protein is highly expressed in most patients with AML. In patients with ALL, FLT3 protein is highly expressed in up to 50% of leukemic blasts. Here, we aimed to evaluate the frequency of FLT3 protein expression in pediatric patients with ALL at South Egypt Cancer Institute, Assiut University, Egypt.