Background: Bone marrow aspiration/biopsy, in patients with hematological cancer, is a painful procedure and may be repeated at regular intervals, so we compared the effects of two different sedative agents (Midazolam and Dexmedetomidine) on haemodynamics, sedation and recovery profile in child patients undergoing bone marrow aspiration/biopsy under conscious sedation with ketamine.
Methods: 100 Child aged 3–12 years with haematological diseases were enrolled in this randomized, double blind study, divided into two groups:
Group I: Patients received midazolam (IV infusion) 0.05 mg/kg. Group II: Patients received Dexmedetomidine (IV infusion) 0.75 µg/kg, and all patients received Ketamine 1 mg/kg intravenously (IV). We started Dexmedetomidine or midazolam infusion over 10 minutes through a peripheral venous cannula, then 5 minutes from the start, ketamine was administered over 10–20 seconds. In both groups haemodynamics, sedation times and Ramsay scores are obtained.
Results: Both dexmedetomidine-ketamine and midazolam-ketamine com¬binations produce stable hemodynamics and satisfac¬tory induction conditions in patients with haematological cancer diseases undergoing bone marrow aspiration. These combinations provide effective sedation with only few side effects and minor hemodynamic fluctuations. With longer sedation time and recovery time were recorded in dexmedetomidine group versus midazolam group.
Conclusion: Dexmedetomidine-ketamine is a better sedative combination than midazolam-ketamine and both preserve haemodynamics stable.
Trial registeration.gov NCT03647579