Background: adjunctive local periodontal therapy is one of the best options to improve the health of the pocket tissue. The comparison of local effects of simvastatin and metformin as aid in enhance the healing of periodontal tissue is the point of importance.Methods: atotal of 45 systemically healthy patients with mild to moderate chronic periodontitis; which having a generalized pocket depth varied from 3mm to 5mm. All patients handled by scaling and root planning and divided haphazardly into: group I, as a control group (n= 15), in which the patients treated by application of placebo gel; group II, (n= 15) treated with application of 1.2% simvastatin gel; group III, (n= 15), treated with application of 1% metformin gel. Clinical and biochemical criteria were collected at threshold 3, 6 and 9 months.Results: an advancement in both plaque and gingival indexes was noticed in total 3 groups at 6 and 9 months. Plaque Index and Gingival Index showed decrement in groups II and III than group I. The cutback in probing depth and clinical attachment loss was higher in the group III than other groups. Significant minimization in both IL-6 and TNF-α levels occurred from baseline to the end of measurement duration in all groups. Clear interaction was established amid IL-6 and TNF-α heights.Conclusion: metformin was comparatively better than simvastatin in respect of clinical and biochemical markers.