Research Abstract
| Aim: This study evaluated the biocompatibility of three different root canal sealers (CeraSeal, NeoSEALER Flo, and AH-Plus) by implanting them into the subcutaneous tissues of rats and analyzing the tissue response through histopathological and immunohistochemical methods.Materials and Methods: Sixty male Calomys callosus (Rodentia, Cricetidae) rats were used. The sealers were placed in polyethylene tubes that were inserted into certain dorsal subdermal locations. After 3, 7, and 30 days, the implants were removed, fixed, and processed for microscopic inspection using a glycol methacrylate-embedding procedure.The descriptive analysis focused on fibrous capsule thickness, severity of the inflammatory response, presence of giant cells, and evidence of biomineralization.Results: CeraSeal and the control group exhibited a milder inflammatory response compared to NeoSEALER Flo and AH-Plus. Additionally, the control group showed the thinnest fibrous capsule, followed by CeraSeal, while AH-Plus demonstrated the thickest capsule.Conclusions: Within the limitations of this study, CeraSeal demonstrated superior biocompatibility compared to NeoSEALER Flo and AH-Plus sealers. |
Research Date
Research Department
Research File
Research Member
Research Publisher
Egyptian Dental Association
Research Vol
71
Research Website
10.21608/edj.2025.383230.3468
Research Year
2025
Research Pages
2735:2749