Aim: Coronavirus disease (COVID-19) was first to appear in Wuhan, China, in 2019. Being highly contagious, it started to spread rapidly throughout the entire world causing fear and anxiety among all nations with a very high mortality rate. Dentists are considered at an extremely substantial risk to be infected among all health care workers because they are working in close contact with their patients and also because of being regularly exposed to the aerosols, droplets and saliva splashing out of the patients’ mouth. Subjects and Methods: This study was based on a questionnaire to assess the knowledge of the graduating dental students about the signs and symptoms of (COVID-19) infection and also to evaluate their awareness about the precautions and infection control measures required during the dental treatment to keep them safe and control the spread of the disease. A well-constructed and validated questionnaire was formed and its link was sent to dental students in all year grades at different universities in Upper Egypt. The data were collected, tabulated, and statistically analyzed by SPSS (Statistical Package for Social Sciences). Results: Result showed significant valued regarding that the dental students have a good understanding of COVID-19 and the precautions. Conclusion: As a result, it was concluded that the dental students have a good understanding of COVID-19 and the precautions that must be taken to provide adequate dental treatment for patients during the pandemic.