The rolling element bearing is a fundamental component of any rotating machinery. During operation, wear debris and lubricant impurities create dents and bumps on the bearing raceway surfaces. Such localized defects produce transient vibration impulses at one of the bearing characteristic frequencies. Having a combination of multiple types of point defects on the raceway results in superimposed vibration patterns, which reduce the ability to recognize these defects’ effects. In this paper, a 6-DOF dynamic model is developed to accurately investigate the vibration characteristic of a ball bearing with a multipoint defect comprising a dent and bump on its raceway surface. The model considers the effects of time-varying contact force produced due to defects, lubricant film damping, bearing preload, and the inertia effect of rolling elements. The simulation results reveal the vibration behavior of multipoint defect bearings. In addition, bearing vibration response is affected by the number of defects, the angle between them, and the type and size of each defect. Furthermore, it is challenging to predict bearing defects parameters such as the numbers, types, sizes, and angles between adjacent defects from acceleration signal analysis without jerk signal analysis. The validation of the model is proved using signals from the Case Western University test setup.