This paper presents an image processing-based approach for the assessment of living cell apoptosis. The approach uses deformable models in tracing the changes in cell shapes in accordance to possible apoptotic cell death. Stochastic controlled energy function is used to drive the evolution of the deformable model. As an application for the proposed approach, it is applied for detecting the morphological changes in exercise-induced immune cells during their apoptosis. The approach is used with the goal of automating the assessment of cell apoptosis. The proposed approach shows promising results in detecting these morphological changes.