Research Member
Research Year
2014
Research Journal
PLoS One
Research Publisher
Public Library of Science
Research Vol
Vol. 9, No. 9
Research Rank
1
Research_Pages
e108128
Research Website
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108128
Research Abstract
Cryopreservation is a key technology in biology and clinical practice. This paper presents a digital microfluidic device that automates sample preparation for mammalian embryo vitrification. Individual micro droplets manipulated on the
microfluidic device were used as micro-vessels to transport a single mouse embryo through a complete vitrification procedure. Advantages of this approach, compared to manual operation and channel-based microfluidic vitrification,
include automated operation, cryoprotectant concentration gradient generation, and feasibility of loading and retrieval of embryos.