This paper addresses the optimal distributed generation sizing and siting for voltage profile improvement, power losses, and total harmonic distortion (THD) reduction in a distribution network with high penetration of non-linear loads. The proposed planning methodology takes into consideration the load profile, the frequency spectrum of non-linear loads, and the technical constraints such as voltage limits at different buses (slack and load buses) of the system, feeder capacity, THD limits, and maximum penetration limit of DG units. The optimization process is based on the Genetic Algorithm (GA) method with three scenarios of objective function: system power losses, THD, and multi-objective function-based power losses and THD. This method is executed on the IEEE 31-bus system under sinusoidal and non-sinusoidal (harmonics) operating conditions including load variations within the 24-hr period. The simulation results using Matlab environment show the robustness of this method in optimal sizing and siting of DG, efficiency for improvement of voltage profile, reduction of power losses, and THD. A comparison with particle swarm optimization (PSO) method shows that the proposed method is better than PSO in reducing the power losses and THD in all suggested scenarios.