A series of identical twin esters 3a-e of metronidazole was synthesized and evaluated as
potential prodrugs with improved physicochemical and pharmacokinetic properties. The
synthesis of the twin esters 3a-e was achieved by interaction of metronidazole with the
respective dicarboxylic acid anhydride or their dichloride. Their structures were verified by
elemental and spectroscopic analyses. The lipophilicity of metronidazole and the prodrugs
3a-e, expressed as Rmvalues, were determined using reversed-phase TLC and revealed