Cisplatin (CP) is a chemotherapy drug that is given
to treat cancer. Oxidative stress has been proven to
be involved in CP-induced nephrotoxicity. The
present study was done to evaluate the role of Vit
C, DPPD and L-cysteine (L-Cys) as antioxidants in
the protection against CP-induced nephrotoxicity.
Forty rats were divided into control and 4 treated
groups injected with CP (8 mg/kg). Group 1 positive
control, G2, G3 and G4 were treated with Vit C (100
mg/kg), DPPD (125 mg/kg) and L-Cys (100 mg/kg)
respectively. Histopathological examinations
revealed severe degenerative and necrobiotic
changes in renal tubules and glomerulei of GI.
These changes became mild in the other groups.
The biochemical results indicated a significant
increase in plasma urea and creatinine in GI. Lipid
peroxides, total peroxides, superoxide anion levels
and DNA fragmentation were significantly
increased, however, the enzymatic antioxidant
activities and the contents of non-enzymatic
antioxidants were decreased compared with the
control rats. Administration of Vit C, DPPD and LCys
with CP counteract the changes in oxidative
stress markers in renal tissues of treated rats with
CP. The present results conclude that DPPD, Vit C
and L-Cys ameliorate the pathological and oxidative
stress-induced by CP in the kidneys of male rats.