Risk genes and autoantibodies in Egyptian children with type 1 diabetes–low frequency of autoantibodies in carriers of the HLA‐DRB1* 04: 05‐DQA1* 03‐DQB1* 02 risk haplotype

كلية الطب

جامعة أسيوط

Risk genes and autoantibodies in Egyptian children with type 1 diabetes–low frequency of autoantibodies in carriers of the HLA‐DRB1* 04: 05‐DQA1* 03‐DQB1* 02 risk haplotype

مؤلف البحث
Mostafa I El‐Amir, Mohamed Ali El‐Feky, Antti‐Pekka Laine, Taina Härkönen, Omnia El‐Badawy, Azza A Eltayeb, Tarek Taha El‐Melegy, Minna Kiviniemi, Mikael Knip, Jorma Ilonen
قسم البحث
قسم طب الأطفال
مجلة البحث
Diabetes/metabolism research and reviews
المشارك في البحث
Azza Ahmed El-Tayeb Issa
تصنيف البحث
1
سنة البحث
2015
ملخص البحث

Background The study aimed to define the frequencies of type 1 diabetes-associated gene
polymorphisms and their associations with various diabetes-associated autoantibodies in
Egyptian children. Methods One hundred and one children with type 1 diabetes and 160
healthy controls from the same region were studied for HLA-DQB1, HLA-DQA1, and HLA-
DRB1 (DR4 subtypes) alleles; for INS and protein tyrosine phosphatase, non-receptor type
22 gene polymorphisms (rs689 and rs2476601); and for diabetes-associated