Skip to main content

COMPARATIVE STUDY BETWEEN THE EFFECT OF MORPHINE AND FENTANYL ON INFLAMMATORY PROCESS AFTER OPEN CARDIAC SURGERY

مؤلف البحث
Seham Mohamed Moeen Ibrahim
Prof. Dr. Laila Hassan Mohammed
Prof. Dr. Fatma Gad El-Rab EL-Sayed Askar
Dr. Sherif Sayed Abdel-Rehim
مجلة البحث
Anesthesia & Clinical
Research
المشارك في البحث
الناشر
Sherif Sayed, Department of Anesthesiology, Assuit
تصنيف البحث
1
عدد البحث
Volume 5 • Issue 6 • 1000412
سنة البحث
2014
صفحات البحث
1-8
ملخص البحث

Thirty patients presented for elective valve replacement surgery were included. The patients were classified into two equal groups (15 each) according to the received opioid as a part of a balanced anesthetic technique. The first group, (morphine group), received morphine IV (0.1 mg/kg) at anesthesia induction and then (1-2 mg/h) till the end of surgery and the arrival to the ICU. The second group, (fentanyl group), received fentanyl IV (5 µg/kg) at anesthesia induction and then (1µg/kg/h) until the end of surgery and the arrival to the ICU. We concluded that, the use of morphine when compared to fentanyl as a part of a balanced anesthetic technique in valve replacement surgery after CPB, can allow better hemodynamic stability, attenuates the release of inflammatory cytokine (IL-6) and anti-inflammatory cytokine (IL-10), produce a greater reduction in adhesion molecule expression (CD 11b, CD 11c and CD 18), and reduce the incidence of postoperative hyperthermia.