Single inhalation of the local Egyptian glue “Kolla”
leads to remarkable decrease in brain GABA levels; which is less
remarkable after repeated inhalation. Kolla single and repeated
inhalation increased both dopamine and 5HT brain levels. Single
and repeated inhalation of Kolla produces remarkable increase
in serum liver enzymes, urea and Creatinine. Inhalation of Kolla
caused no obvious effect on reference or working memory. Kolla
(5000 ppm) did not affect unconditioned or conditioned reflexes.
In a concentration of 10,000ppm it caused loss of both reflexes.
Repeated daily inhalation of Kolla displayed marked histopathological
changes in brain tissues