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Immunogenicty of recombinant hepatitis B vaccine among routinely vaccinated healthy and chronically ill children in Assiut Upper Egypt

مؤلف البحث
: د/ اسامه العشير , د/ منال درويش , د/ مادلين عادل عطية , د/ خالد سعد
مجلة البحث
Gastroenterol Res. 2015;8(3-4):222-227
المشارك في البحث
الناشر
NULL
تصنيف البحث
1
عدد البحث
NULL
موقع البحث
NULL
سنة البحث
2015
صفحات البحث
NULL
ملخص البحث

NULLAbstract
Background: Egypt is considered a region of the intermediate prevalence
of hepatitis B virus (HBV) infection (4.5%). Seroprotection is assured
when hepatitis B surface antibody (HBsAb) levels are ≥ 10 mIU/
mL. Our study aimed to evaluate and compare the long-term immunogenicity
and efficacy of the recombinant hepatitis B (HB) vaccine.
Methods: A cross-sectional study was done for children aged from 9
months to 15 years, receiving health care at Assiut University Children’s
Hospital, Assiut, Egypt in 3 months. HBsAb was quantitatively
determined by enzyme-linked immune sorbent assay (ELISA).
Results: Seroprotection in infants less than 1 year was 89.7% with
55.2% having titer > 100 mIU/mL and this percent dropped to 64.4%
after the first year of age with only 29% having titer > 100 mIU/
mL. The overall protection percentage was 32.5% (> 100 mIU/mL),
34.7% of children showed levels between 10 and 100 mIU/mL, while
32.8% were less than 10 mIU/mL. Patients with diabetes mellitus
were found to have the lowest seroprotective levels (83.3% were not
protected). Non-protective levels were also detected in patients with
malnutrition (55.6%), congenital heart diseases (43.2%) and chronic
liver diseases (57.1%).
Conclusion: Our study shows failure to achieve satisfactory seroprotective
levels for hepatitis B vaccine in both healthy and diseased
children who adopted vaccination schedule in Upper Egypt. Booster
dose in the second year of life is recommended for all children, particularly
for those with diabetes millets, congenital heart disease and
malnutrition.
Keywords: Immunogenicity; Hepatitis B vaccine; Children