Background: Chronic hepatitis C is the most common cause of chronic liver
disease and cirrhosis. Egypt is the highest affected country with a prevalence of
22%. In children, seroprevalence of HCV is 0.2% in children less than 11 years
of age and 0.4% in children equal and more than 11 years of age.
Aim of the work: The purpose of this study was to assess the value of 1H MRS
and DW-MRI as non invasive tool in evaluation of activity and fibrosis of
hepatic parenchyma in asymptomatic children with chronic hepatitis C.
Subjects and Methods: Across-section study was conducted over a period of
two years, included thirty children of asymptomatic chronic hepatitis C virus
infection (mean age + SD 14.1+2.8 years) and twenty healthy children as
controls were included. Abdominal ultrasonography, Percutaneous liver biopsy,
MRS and DW-MRI were done to all cases.
Results: The results showed HCV infection was more common in our males
(83.3%). The results of METAVIR grades showed 29 cases (99.9%) had
activity while 17 cases (56.4%) had fibrosis. The results of MRS& DW-MRI
showed significant differences between cases and controls and positive
correlations between of the results of 1H MRS with the results of liver biopsy
(METAVIR Grades and METAVIR Stages).
Conclusion: Early diagnosis of asymptomatic chronic hepatitis C is essential to
prevent or delay end stage chronic parenchymal liver disease. 1H MRS may be a
potential non-invasive helpful diagnostic tool in assessment the staging andfibrosis of asymptomatic chronic hepatitis C. As the increased of its
metabolites were correlated with histopathological changes. DW-MRI can be
considered an effective predictor in assessment of activity in chronic hepatitis
C.
قسم البحث
مجلة البحث
Egyptian journal of radiology and nuclear medicine
المشارك في البحث
الناشر
Elsevier
تصنيف البحث
1
عدد البحث
47
موقع البحث
NULL
سنة البحث
2016
صفحات البحث
739-748
ملخص البحث