Objective : to evaluate the efficacy and the safety of Magnesium sulphate infusion in prevention of post-operative atrial fibrillation AF in adult cardiac surgeries
Design Prospective, randomized, clinical trial.
Setting: Assiut university hospital
Participants: 40 adult patients undergoing valve replacement or coronary artery bypass grafting.
Measurements and Main Results: patients were randomly allocated into two groups, group C is the control group, and group M which is study group and will receive 10 mmol of magnesium sulphate (2.47 gm) which in 100 ml of saline solution infused intravenously over 4 hours, once daily for 3 days starting when the patient is shifted to ICU. Demographic Patient characteristics, type of operation were recorded in addition to echocardiography findings. kidney function tests, arterial blood gases, serum electrolytes (Na+, K+, Ca+2 Cl-, Mg+2 and P+2) were all recorded preoperative and after separation from cardiopulmonary bypass and shifting to the ICU, all hemodynamic data and respiratory rate were recorded starting from the immediate post bypass period and then every 24 hours for the next two days. The incidence of AF was significantly lower in group M, with the maintenance of normal levels of other serum, electrolytes , arterial blood gases , and kidney function .