Background: Athough hypothyroidism has insidious onset and relatively asymptomatic, exertional dyspnea and fatigue can be the presenting complaints.Objectives: To assess functional lung impairment in hypothyroid patients both at rest and during exercise. Patients and methods: A case control study was carried out on 42 patients with newly diagnosed hypothyroidism and 12 control subjects. Hypothyroidism was diagnosed based on high value of thyroid stimulating hormone TSH≥ 6 uIU/ml, and low value of FT4≤ 0.8 ng/dl, both groups had chest x ray, spirometry, diffusing capacity for carbon monoxide DLCO, arterial blood gases(ABG) and symptom limited exercise testing using treadmill. Results: Both groups were comparable as regard age, sex and body mass index. Although ABG and spirometry were within normal in both groups, FVC%, and FEF25-75%were significantly reduced in hypothyroid group(P 0.014, 0.000 respectively), DLCO significantly reduced in hypothyroidism( P 0.005). As regard exercise testing parameters, maximum oxygen consumption VO2%, minute ventilation VE, tidal volume VT, and oxygen pulse VO2/HR were significantly reduced in hypothyroidism (0.005, 0.000, 0.000, and 0.02 respectively). TSH significantly negatively correlated with FEV1%, FEF25-75%, and DLCO while they significantly positively correlated with FT4 Conclusion: Even with presence of normal chest x ray , arterial blood gases, and spirometry in patients with hypothyroidism DLCO and exercise testing parameters can be significantly reduced.
قسم البحث
مجلة البحث
Annals of Thoracic Medicine
المشارك في البحث
الناشر
NULL
تصنيف البحث
1
عدد البحث
Vol. 12
موقع البحث
NULL
سنة البحث
2017
صفحات البحث
pp. 204 - 208
ملخص البحث