Objective: To compare the hormonal-metabolic profiles and reproductive outcomes in clomiphene-resistant
patients with polycystic ovary syndrome and insulin resistance between women receiving metformin and
those undergoing laparoscopic ovarian drilling. Methods: A total of 110 eligible participants were randomly
allocated to diagnostic laparoscopy plus metformin therapy (group 1, n=55) or laparoscopic ovarian drilling
(group 2, n=55). The t test was used for mean comparisons of hormonal-metabolic parameters and OGTT
values before and after treatment. The χ2 test was used for comparisons of ovulation, pregnancy, and
abortion rates. Results: Groups 1 and 2 showed a significant decline in testosterone, insulin-like growth
factor-1 (Pb0.001 vs Pb0.001), and luteinizing hormone (Pb0.05 vs Pb0.001), while the glucose to insulin ratio
was significantly increased (Pb0.001 vs Pb0.05) compared with baseline. Group 2 patients had more regular
cycles and higher rates of ovulation and pregnancy compared with group 1: 76.4% [42/55] vs 58.2% [32/55],
Pb0.04; 50.8% [131/258] vs 33.5% [94/281], Pb0.001; and 38.2% [21/55] vs 20.0% [11/55], Pb0.03, respectively.
The difference in the early abortion rate between the groupswas not statistically significant. Conclusion: Although
metformin results in a better attenuation of insulin resistance, laparoscopic ovarian drilling is associated with
higher rates of ovulation and pregnancy.
قسم البحث
مجلة البحث
International Journal of Gynecology and Obstetrics
المشارك في البحث
الناشر
Science Direct
تصنيف البحث
1
عدد البحث
108
موقع البحث
NULL
سنة البحث
2010
صفحات البحث
143-147
ملخص البحث