Purpose: To measure SSI rates among gastrointestinal surgeries and to identify the associated risk factors. Patients and methods: We conducted a multicenter retrospective surveillance-based study of adults undergoing gastric, colon and small bowel (SB) procedures from January to December 2016. Univariate and multivariate analyses performed to determine the predictive variables in each surgery. Results: 71 patients out of 2099 developed SSI; 0.8%, 19.8%, and 10.8% following gastric, colon, and SB surgeries respectively. In gastric surgery risk factors identified by univariate analysis were age, duration, wound class, risk index, emergency and scope use (P<0.05). Logistic regression analysis revealed that laparoscopic approach was the only significant predictor with inverse relationship with SSI rate versus open gastric surgery (P<0.05). Prolonged duration was the significant risk factors for developing SSI in colon surgery and emergency was a significant risk for development of SSI in SB surgery. Gram negative bacilli were the main causative pathogens; with high percentage of MDROs. Conclusion: Variances in SSI rates and risk factors among gastric, colon and SB surgery were detected. The use of endoscope in gastric surgeries exhibited a protective effect against development of SSI. The reduction of SSI rate can be achieved by targeted preventive interventions for the identified risk factors.