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Reno- protective effects of urodeoxycholic acid against gentamycin-induced nephrotoxicity through modulation of NF-kB, eNOS and caspase-3 expressions.

مؤلف البحث
Tarek Hamdy Abd-Elhamid, Dalia EL gamal, Safaa S. Ali, Fares E. M. Ali, Emad H. M. Hassanein, Ehab A. M. El-Shoura, Ramadan A. M. Hemeida
مجلة البحث
cell and tissue research
المشارك في البحث
الناشر
NULL
تصنيف البحث
1
عدد البحث
NULL
موقع البحث
NULL
سنة البحث
2018
صفحات البحث
NULL
ملخص البحث

Gentamicin (GNT) is a potent aminoglycoside antibiotic widely used to treat life-threatening bacterial infections. We aim to investigate the potential protective effect of ursodeoxycholic acid (UDCA) against GNT-induced nephrotoxicity. In this study, 24 male Wistar rats were used and randomly divided into four groups of six animals each. Control group received 0.5% carboxymethyl cellulose orally for 15 days, GNT group received GNT 100 mg/kg/day ip for 8 days, UDCA group received UDCA orally for 15 consecutive days at a dose of 60 mg/kg/day suspended in 0.5% carboxymethyl cellulose and UDCA-pretreated group received UDCA orally for 7 days then co-administered with GNT ip for 8 days at the same fore-mentioned doses. Serum levels of kidney function parameters (urea, creatinine, uric acid and albumin) were measured. Renal tissues were used to evaluate oxidative stress markers; malonaldehyde (MDA