Introduction. Peripheral nerve injury is
a frequently encountered clinical problem
that leads to functional losses at the long-
-term. Although microsurgical repair has
been introduced to clinical practice in
peripheral nerve injuries, unsatisfactory
outcomes regarding functional recovery in
target organ cause an increasing interest
on studies about nerve injury and biology
of the recovery in nerve injuries1.
Material and Methods. Sciatic nerves of
seventy adult Sprague Dewly rats were
transected and primary anastomosis was
performed. Rats were then divided into
three groups: Control group, while 30
rats were repaired with sutures, and the
remaining 30 were repaired with fibrin
glue. After 30 days the rats were sacrified
and the sciatic nerves were investigated
histologically with morphometrical and
statistical analyses.
Results. In microsurgical nerve repair,
suture placement has been thought to
cause hindrance to the sprouting axons
and compress the blood supply to the fascicles,
thereby impairing the regeneration
of the transected nerve ends after repair,
with possible neuroma formation. On the
other hand, fibrin glue is a simple, effective
technique, less time consuming than suturing.
Another advantage of this suture-free
technique is that it avoids injuring the axon
with needles, and the lack of foreign bodies
minimizes the inflammatory reaction.
Conclusion. We recommend using fibrin
glue as it demonstrates less inflammatory
reaction, less scar tissue formation, it is
less time consuming and provides better
outcomes.