Abstract
Sexual dysfunction is more prevalent in psychotic patients than in the nonpsychotic
population. The objective of this study was to identify correlations between serum
prolactin levels, testosterone levels and erectile dysfunction in patients with firstepisode
psychosis (n = 40) compared to age-matched healthy controls (n = 40). All
subjects underwent clinical evaluation, international index of erectile function (IIEF5)
score assessment and measurement of serum prolactin and total testosterone levels.
In first-episode psychotic patients, the IIEF-5 score and total testosterone levels
were significantly lower, while serum prolactin levels were higher. We concluded that
men with first-episode psychosis are at an increased risk for development of erectile
dysfunction, and increased duration of untreated psychosis leads to a higher incidence
of erectile dysfunction and hyperprolactinemia.