Abstract   Background:  Lung  cancer  is  the  main  cause of  cancer  deaths  worldwide.  It is  important to identify  the prognostic  factors  of  this  disease  which  leads  to  low  survival  times  despite  the  advancing  treatment  modalities.  Aim: To  investigate  the  role  of  clincopathological  parameters  and  treatment  modality  as  a  prognostic  factors  affecting survival  of  patients  with  advanced non-small cell  lung  cancer  (NSCLC).  Methods:  We retrospectively  reviewed  the clinical  records  of  patients  with  inoperable  stage  III/IV  NSCLC,  who  were  treated  at  the  department  of  Clinical Oncology,  Assiut  University  Hospital  between  2009 and 2014.  The  association  between  the  demographic  and clinical  characteristics  and  survival  of  these patients  was  analyzed.  Results:  A  total of  69  patients  (32  stage  III& 39 stage  IV)  were  identified  and  included  in this  study.  Sex  (males  vs.  females,  p=0.04),  Eastern  cooperative  Oncology group performance  status  (0 vs.  1 vs.  2,  p=0.001),  smoking  habit  (never  vs.  current  vs.  former,  p=0.001),  stage  (IIIA vs.  IIIB  vs.  IV,  p=0.008)  and the  initial  treatment  (no  vs.  chemotherapy  vs.  concurrent  chemoradiotherapy,  p=0.001) were found  to  be factors  affecting  survival  in  univariate  analyses.  Sex  and  histological  subtype did  not  affect survival.  Performance status,  stage and  initial  treatment  were determined  as  the independent  prognostic  factors affecting  survival in  multivariate  analyses.  Conclusion:  Performance  status,  stage  and  initial treatment  with concurrent  chemoradiotherapy  in  eligible patients  were prognostic  factors  affecting  overall survival  of  patients  with advanced  NSCLC. Keywords:  non-small  cell  lung cancer,  prognostic  factors,  survival