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Acetylated Bovine Whey Supplement Superseded the Hepatoprotective Action of NAC Drug in Iron Overloaded Rats

مؤلف البحث
Ahmed Y Nassar1*, Madiha M Makhlouf2 , Abo Bakr M El-Tayeb3 , Randa Thamir1 , Esraa Abdel Ghany Sayed4 , Gamal AY Nassar5 and Amany Abdel Rahman Osman6
تاريخ البحث
مجلة البحث
Journal of Nutrition and Health Sciences
المشارك في البحث
الناشر
Annex Publishers
عدد البحث
10(2)
موقع البحث
https://www.annexpublishers.com/articles/JNH/10204-Acetylated-Bovine.pdf
سنة البحث
2023
ملخص البحث

In this study, prepared acetylated bovine whey (ABW) was tested as a highly efficient hepatoprotective agent like that of the old drug N-acetyl cysteine (NAC) against the induction of iron overloading (IO) in a rat model. The probably prophylacting antioxdative characteristic features that were prominently executed on tissue content of reactive oxygen species (ROS), antioxidative ferritin, and proinflammatory IL-6 via the enhanced tissue protecting Nf-E2-related factor 2 (Nrf2) pathway. The reduction in macrophagic M2 CD163 and Kupffer M1 CD68 as well as apoptotic caspase 3 distribution denoted the efficacy of the targeting cellular prophylacting activity. In addition, the reduced abnormalities in the hepatocellular nuclei, cytoplasmic reticulum, mitochondrial degeneration as well as granular glycoproteins, and secondary lysosomal appearance promoted the more preferable usage of the natural product whey supplement than the risky NAC in IO cases.