Background
Behçet’s disease (BD) is considered a chronic multisystem disorder, where
neurological manifestations are common. There is scarcity of investigations that
have assessed the autonomic nervous system dysfunction in BD, with conflicting
results.

Objectives
The current study aimed to identify presence of autonomic nervous system
dysfunction using neurophysiological assessment in BD and to investigate the
relationship between the indicators of autonomic function and the disease activity
parameters.

Patients and methods
The study involved 30 patients with BD in accordance with the Universal Criteria for
Behçet’s Diseases and 25 controls, who were subjected to clinical evaluation and
Palmar sympathetic skin response (SSR).

Results
Patients with BD had a significant difference in SSR (P<0.001) compared with
controls. Moreover, a significant positive association was found among neuropathic
pain and disease activity parameters.

Conclusion
The study confirms the presence of sympathetic autonomic dysfunction in BD,
which related to disease activity using a simple noninvasive test such as SSR.